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Climate change is a major challenge in natural resource management, both because of the magnitude of potential effects and because of the uncertainty associated with climate change projections and effects. Adapting resource management to changing conditions is critical to reduce the vulnerability of key natural and human systems to negative climate change effects, and to ensure continued functionality of terrestrial and aquatic ecosystems in the future. Significant progress has been made in climate change vulnerability assessment and adaptation in natural resource management over the last decade, and key sensitivities and adaptation practices have emerged from these efforts. Here, we synthesize key climate change sensitivities and risk management practices for forest vegetation, non-forest vegetation, water and infrastructure, fisheries and fish habitat, wetlands and riparian areas, wildlife, and recreation.